Background and objectives: Definitions of medical futility, offered by healthcare professionals, bioethicists and other experts, have been rigorously debated by many investigators, but the perceptions of patients of futility have been explored only by a few. Patients were allowed to discuss their concerns about end-of-life care, so that their ideas about treatment futility or utility could be extrapolated by us.Methods: In this cross-sectional study, in-depth, semistructured interviews were conducted with 30 elderly people who were receiving outpatient care in a large, (...) urban Veterans Affairs medical centre in the US. Each of their healthcare providers was also interviewed. Participants were asked to consider four terms commonly used in advance directive forms and to discuss what these terms meant to them. Audiotapes of the open-ended interviews were transcribed and responses were coded and categorised by constant comparison, a commonly used qualitative method.Results: The following four factors were taken into account by the participants when discussing end-of-life interventions and outcomes: expected quality of life; emotional and financial costs of treatment; likelihood of treatment success; and expected effect on longevity.Conclusions: Although the terms “utility” or “futility” were not generally used by the participants, segments of speech indicating their perceptions of these terms were identified. Treatment was not always discussed in the same way by patients and providers, but seemed to reflect the same four concerns. Therefore, it may be fruitful for providers to focus on these concerns when discussing end-of-life treatment options with their patients. (shrink)

Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into apoptotic (...) bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis. (shrink)

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and (...) typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect (delayed response due to interference) elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

Previous research suggests that free will beliefs and moral responsibility beliefs are strongly linked, yet ultimately distinct. Unfortunately, the most common measure of free will beliefs, the free will subscale (FWS) of the Free Will and Determinism Plus, seems to confound free will beliefs and moral responsibility beliefs. Thus, the present research (1,700 participants across two studies) details the development of a 2-factor FWS – the FWS-II – that divides the FWS into a free will subscale and a moral responsibility (...) subscale. The FWS-II showed good fit compared to standard fit thresholds and superior fit compared to the original FWS. The moral responsibility subscale was moderately correlated with general punitive attitudes and specific punitive assignments, even when controlling for the free will subscale. Conversely, the free will subscale was moderately correlated with conservativism and religiosity, even when controlling for the moral responsibility subscale. These results provide evidence that the FWS is better suited – psychometrically, theoretically, and practically – as a 2-factor measure of free will beliefs and moral responsibility beliefs than as a 1-factor measure of free will beliefs. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

We examine ethical considerations in access to facial transplantation (FT), with implications for promoting health equity. As a form of vascularised composite allotransplantation, FT is still considered innovative with a relatively low volume of procedures performed to date by a small number of active FT programmes worldwide. However, as numbers continue to increase and institutions look to establish new FT programmes, we anticipate that attention will shift from feasibility towards ensuring the benefits of FT are equitably available to those in (...) need. This manuscript assesses barriers to care and their ethical implications across a number of considerations, with the intent of mapping various factors relating to health equity and fair access to FT. Evidence is drawn from an evolving clinical experience as well as published scholarship addressing several dimensions of access to FT. We also explore novel concerns that have yet to be mentioned in the literature. (shrink)

ABSTRACT BACKGROUND: The objective of this study was to identify factors motivating women to take part in endometriosis research and to determine if these factors differ for women participating in clinical versus basic science studies. METHODS: A consecutive series of 24 women volunteering for participation in endometriosis‐related research were asked to indicate, in their own words, why they chose to volunteer. In addition, the women were asked to rate, on a scale of 0 to 10, sixteen potentially motivating factors. The (...) information was gathered in the form of an anonymous self‐administered questionnaire. RESULTS: Strong motivating factors (mean score >8) included potential benefit to other women's health, improvement to one's own condition, and participation in scientific advancement. Weak motivating factors (mean score <3) included financial compensation, making one's doctor happy, and use of ‘natural’ products. No difference was detected between clinical and basic science study participants. CONCLUSION: This study is the first study to specifically investigate the factors that motivate women to take part in endometriosis research. Understanding why women choose to take part in such research is important to the integrity of the informed consent process. The factors most strongly motivating women to participate in endometriosis research related to improving personal or public health; the weakest, to financial compensation and pleasing the doctor. (shrink)

The Hierarchical Taxonomy of Psychopathology (HiTOP) emerged to address critical shortcomings inherent to traditional psychiatric classification systems such as the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases, notably their categorical structure, high comorbidity across categories, and within-diagnosis heterogeneity. HiTOP adopts an empirically derived, dimensional, and hierarchical approach, organizing psychopathological phenomena based on their patterns of observed covariation. This paper explores essential conceptual and philosophical considerations around HiTOP, examining its theoretical assumptions about dimensionality and hierarchy, the (...) nature and interpretation of latent variables, the notion of psychopathology, considerations around validity, and the role of epistemic and non-epistemic values in shaping scientific objectivity. HiTOP is a descriptive model based on quantitative evidence (such as taxometric and factor-analytic approaches), but it is also a nosological project that exists within a particular sociocultural and historical context. As an illustration of the role of values, the applicability of HiTOP to marginalized minority populations is discussed, highlighting ongoing efforts toward ensuring inclusivity and representational equity. By addressing these conceptual foundations, this paper lays groundwork essential for future philosophical inquiry, empirical research, and practical applications of the HiTOP framework. (shrink)

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and (...) typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods. (shrink)

Este trabajo surge a partir de la investigación general de las técnicas hidropónicas teniendo en cuenta sus ventajas y desventajas para de esta forma poder encontrar aquel factor determinante a través de una comparación de técnicas hidropónicas que permitan clasificarlas y escoger la mejor opción que genere menos impacto ambiental negativo y demuestre ser más productivo en los entornos urbanos. Adicionalmente, un factor determinante en las ciudades es su espacio limitado por lo que la mejor opción también deberá incluir un (...) óptimo manejo del espacio que permita a casi cualquier individuo poder aplicarlos desde su entorno sin recurrir a excesivas modificaciones. Como principal resultado se escogió a la Hidroponía recirculante como método predominante por los excelentes resultados que se obtienen con relación a los demás, adicionalmente, este puede ser fácilmente aplicado en los ambientes urbanos por su versatilidad y buen manejo de recursos. Palabras Clave: Hidroponia, ambiente, urbano, comparativa, técnicas, cultivo. Referencias [1]J. López, «La producción hidropónica de cultivos,» IDESIA, vol. 36, nº 2, pp. 139-141, 2018. [2]J. Lee, A. Rahman, J. Behrens, C. Brennan, B. Ham, H. Seok Kim, C. Won, S. Yun, H. Azam y M. Kwon, «Nutrient removal from hydroponic wastewater by a microbial consortium,» New Biotechnology, vol. 41, pp. 15-24, 2018. [3]H. Ku, C. Tiong, A. Suresh y B. Ong, «“Active” hydroponic greenhouse system to kick-start and augment reforestation program through carbon sequestration e an experimental and theoretical feasibility study,» Journal of Cleaner Production, vol. 129, pp. 637-646, 2016. [4]J. Beltrano y D. Gimenez, Cultivo en hidroponía, Buenos Aires: Universidad de la Plata, 2015. [5]L. Ramírez, M. Pérez, P. Jiménez, H. Giraldo y E. Gómez, «Evaluación preliminar de sistemas acuapónicos e hidropónicos en cama flotante para el cultivo de orégano,» Revista Facultad de Ciencias Básicas, vol. 7, nº 2, pp. 242-259, 2011. [6]S. Hosseinzadeh, D. Testai, M. BKheet y J. De Graeve, «Degradation of root exudates in closed hydroponic systems using UV/H2O2: Kinetic investigation, reaction pathways and cost analysis,» Science of the Total Environment, vol. 1, pp. 1-9, 2019. [7]N. Camarena, A. Rojas y M. Santos, «Fluoride bioaccumulation by hydroponic cultures of camellia,» Chemosphere, vol. 136, pp. 56-62, 2015. [8]W. Wang, Y. Ma, L. Fu, Y. Cui y M. Yaqoob, «Physical an mechanical properties of hydroponic lettuce for automatic harvesting,» Informatión processing in agriculture, vol. 1, pp. 2214-3173, 2020. [9]M. Zárate, Manual de Hidroponia, Coyoacán: Universidad Autónoma de Mexico, 2014. [10]S. Magwaza, L. Magwaza, A. Odindo y C. Buckley, «Partially treated domestic wastewater as a nutrient source for tomatoes grown in a hydroponic system: effect on nutrientabsorption and yield,» Heliyon, vol. 6, nº 12, pp. 2405-8440, 2020. [11]C. ARANO, «Hidroponía: Algunas paginas de historia,» Tecnología de Producción, nº 58, pp. 24-32, 2007. [12]G. Guzmán, Hidroponia en Casa: Una actividad familiar, Costa Rica: Ministerio de Agricultura y ganaderia, 2004. [13]J. Gilsanz, HIDROPONIA, Montevideo : Unidad de Comunicación y Transferencia de Tecnología, 2007. [14]C. Miller, «El debate de hidroponia orgánica: Perspectivas norteamericanas sobre si la producción hidropónica merece ser certificada como orgánica.,» Productores de Hortalizas, nº 6, pp. 36-38, 2017. [15]A. Herrera, «Manejo de la solución nutritiva en la producción de tomate en hidroponía,» Terra Latinoamericana, vol. 17, nº 3, pp. 221-229, 1999. [16]C. Espinal y D. Matulić, «Recirculating Aquaculture Technologies,» Biomedical and Life Sciences, pp. 35-76, 2020. [17]H. Resh, «Técnicas de cultivo con flujo laminar de nutrientes,» de Cultivos Hidroponicos, España, Mundi-Prensa, 2001, pp. 35-37. [18]P. Blanca y L. Teresa, «Sistemas recirculantes y su interés en el cutlivo de ornamentales,» Tecnología de producción, nº 35, pp. 34-36, 2006. [19]C. Magán, «Recirculación de las soluciones nutritivas, Manejo y Control Microbiologico,» InfoAgro, nº 2, pp. 1-2, 2016. [20]S. Goddek, A. Joyce, B. Kotzen y M. Dos-Santos, «Aquaponics and Global Food Challenges,» Aquaponics Food Production Systems. Springer, vol. 1, nº 1, pp. 3-17, 2019. [21]S. G. Verdoliva, D. Gwyn Jones, A. Detheridge y P. Robson, «Controlled comparisons between soil and hydroponic systems reveal increased water use efficiency and higher lycopene and β-carotene contents in hydroponically grown tomatoes,» Scientia Horticulturae, pp. 3002-4238, 2020. [22]A. Chaudhry y V. Mishra, «A Comparative Analysis of Vertical Agriculture Systems in Residential Apartments, » de 2019 Advances in Science and Engineering Technology International Conferences, Dubai, United Arab Emirates, United Arab Emirates, 2019. [23]T. Mazhar, G. Jianmin, L. Imran, S. Kashif, Q. Waqar, S. Sher y C. Jiedong, «Modern plant cultivation technologies in agriculture under controlled nvironment: a review on aeroponics,» Journal of Plant Interactions, vol. 13, nº 1, pp. 338-352, 2012. [24]K. Janiak, A. Jurga, J. Kuźma, W. Breś y M. Muszyński, «Surfactants effect on aeroponics and important mass balances of regenerative life support system – Lettuce case study,» Science of the Total Environment, vol. 718, nº137324, pp. 1-12, 2020. [25]F. Rahman, I. Jahan, R. Biplob, N. Farhin y J. Uddin, «Automated Aeroponics System for Indoor Farming using Arduino,» de 2018 Joint 7th International Conference on Informatics, Electronics & Vision and 2018 2nd International Conference on Imaging, Vision & Pattern Recognition, Kitakyushu, Japan, 2018. [26]M. Caldeyro Stajano, «La Hidroponía Simplificada como Tecnología apropiada, para implementar la Seguridad Alimentaria en la Agricultura Urbana.,» Cuadernos del CEAgro, nº 8, pp. 71-76, 2006. (shrink)

Purpose This study aims to develop a normative ethical framework for crisis communication and accountability in algorithmically managed transportation systems. It examines how transparency, responsibility, justice and care should be ethically operationalized when crises arise from complex socio-technical coordination rather than from isolated human error. Design/methodology/approach This study uses a structured narrative synthesis (2020–2025) across crisis communication ethics, information ethics, algorithmic governance and transport regulation to construct a multi-layered normative framework, which is subsequently used to interpret a public aviation disruption (...) linked to revised Flight Duty Time Limitation regulations in India as a theory illustrating a vignette rather than an empirical test case. Findings Four systemic ethical failures are identified: opacity in algorithmic crisis communication, diffusion of accountability across design-time and runtime actors, unjust distribution of disruption-related burdens and remedies and insufficient care for vulnerable passengers. These are translated into operational governance requirements, including impact assessments, traceability, fairness audits and care-sensitive communication architectures. Research limitations/implications As a conceptual study supported by a public vignette, the framework does not offer empirical generalization and requires validation across transport modes and institutional contexts. Practical implications The framework provides regulators, transport operators and technology vendors with actionable guidance for designing enforceable crisis communication, accountability structures and passenger protection mechanisms under algorithmic coordination. Social implications This study highlights how algorithmic crisis coordination can amplify social vulnerability, exclusion and public distrust, particularly affecting elderly, disabled, medically dependent and digitally marginalized passengers. Originality/value This study does not merely assemble existing ethical principles; it reconfigures transparency, accountability, justice and care into a crisis-specific governance architecture that links design-time and runtime accountability, channel-level crisis communication requirements and enforceable institutional mechanisms for algorithmically managed transport systems. (shrink)

Over the past two decades, there has been a growing political and intellectual retrospection on the brittleness, limitations, successes, and failures of liberal democracy and liberalism as a doctri...

This paper revisits the conservative thought of Shirley Robin Letwin, a key intellectual of the New Right and the LSE Right, as well as a prominent defender of Thatcherism. It situates Letwin within the intellectual milieu of the New Right, emphasising both her contributions to Thatcherite ideas and her broader defence of Thatcherite conservatism. Letwin’s political philosophy rests on a sceptical outlook shaped by Hume, Oakeshott, and Hobbes, rejecting rationalist and liberal universalism in favour of tradition, authority, and historical practice. (...) Central to her work is the concept of “conservative individualism”: a moral individualism embodied in the English gentleman as the exemplar of liberty in character. The paper examines her thought in relation to scepticism – exemplified in her critique of liberal rationalism – her defence of individuality, law and civil association, and her interpretation of Thatcherism as a project of moral restoration through the revival of the “vigorous virtues”. While acknowledging the limits of Letwin’s conservatism, the article argues that her account of conservative individualism not only illuminates the intellectual defence of Thatcherism but also retains contemporary resonance for understanding the enduring dilemmas of modern conservatism. (shrink)

This theoretical synthesis presents a unified model of consciousness that reconciles the persistent unity of subjective experience with the constant physical flux of the brain. It integrates two previously proposed frameworks—(1) the high probability of an afterlife and (2) the continuity and uniqueness of consciousness—into a single, testable biophysical theory. The core of this model is the Two-Particle Quantum Bonding Hypothesis (TPQBH), which posits that the stream of consciousness is mediated by two non-energetic, ultra-quantum particles: the Universal- ultra Quantum Genomic (...) Particle of Consciousness (X-UQGPC), which enables bonding with any viable neural substrate, and the Universal- ultra Quantum Unique Particle of Consciousness (X-UQUPC), which ensures the absolute singularity of each conscious perspective. During normal waking states, these particles are resonantly coupled to the brain’s global electromagnetic field, generated primarily by ionic dynamics across neural membranes. States of suspended consciousness, such as general anesthesia or deep sleep, are explained not by particle detachment, but by a reversible magnetic field symmetry that temporarily neutralizes this resonance. At biological death, the irreversible collapse of the global neural field causes the particles to detach and instantaneously re-bond with another compatible nervous system in the universe, preserving an unbroken continuum of awareness. A critical corollary is that a revived corpse would not host the original person, as its continuum has migrated. Furthermore, the theory predicts that no static EEG or MEG signature can define a person, as the brain's physical architecture and resultant electromagnetic field are in perpetual change from development, learning, aging, and neurogenesis. Complementing this physical model, the Mind Virus Framework describes how self-propagating cognitive-emotional patterns influence the brain’s field coherence, thereby modulating the quality of conscious experience. This integrative review bridges quantum biology, neuroscience, and psychology, proposing a naturalistic yet non-materialist mechanism for the continuity of self and offering a scientific foundation for contemplative practices aimed at cultivating mental well-being . (shrink)

Does conscious brain state leave a measurable trace in single neurons? Here I propose a direct electrophysiological test. Using within-neuron patch-clamp recordings across wakefulness, anesthesia, and recovery, I predict that action potentials from the same neuron will show reversible shifts in spike threshold of 0.5 - 3 \mathrm{mV} that correlate with conscious state. This prediction is falsifiable using existing techniques in human cortical neurons during awake craniotomy. Detection of such shifts would challenge the assumption that intrinsic neuronal dynamics are determined (...) solely by local membrane biophysics. The framework also predicts amplification of these effects in long-term meditators and their developmental emergence with network integration. This work transforms a philosophical question about consciousness into an empirically tractable neuroscience experiment. (shrink)

The unique and continuous nature of subjective experience—the persistent "I" that unifies a lifetime of perceptions—represents the most profound unsolved problem in science. While modern neuroscience has made substantial progress in identifying the neural correlates of conscious states, leading theories, including the Global Neuronal Workspace Theory (GNWT), Integrated Information Theory (IIT), and the Orchestrated Objective Reduction (Orch-OR) model, provide mechanistic accounts of awareness but fail to explain the unicity and temporal persistence of the self. These theories cannot logically resolve scenarios (...) of physical disruption or perfect replication. Here, we introduce a fundamental theoretical framework positing that the unique, streaming character of consciousness necessitates a physical principle beyond emergent neural computation. Through a series of rigorous thought experiments—brain revival, molecular disassembly/reassembly, and synthetic replication—we demonstrate the categorical failure of existing models to account for the self. We propose that a unique, non-local identity factor, potentially operating on principles extending current quantum physics, binds to the specific magnetic field topologies of a complex neural system. This "Consciousness Identity Factor" (CIF) hypothesis provides a parsimonious resolution to the duplication paradox and the problem of personal identity. Our framework is fully compatible with established neuroscience while generating specific, falsifiable predictions for studies of anesthesia, brain revival, meditation, and quantum biology. This theory bridges the explanatory gap between the objective brain and subjective identity, proposing a new physical paradigm for the most intimate fact of our existence. (shrink)

For over a century, physics has pursued a unified description of nature linking quantum mechanics, relativity, and cosmology, yet consciousness—our direct window into existence—remains unaccounted for. This review proposes that consciousness continuity is not an emergent accident of neural complexity but a quantum informational invariant, conserved across transformations of its physical substrate. Grounded in the empirical absence of “zombie” organisms and extended through a synthesis of quantum information theory, cosmological logic, and the author’s previous Two-Particle Quantum Bonding Hypothesis (TPQBH), the (...) framework introduces a Quantum Informational Bonding (QIB) mechanism operating within a universal Hilbert space. This mechanism preserves an identity parameter (????₍C₎) analogous to conservation laws in physics. The resulting cosmological model implies an infinite, centre-less universe and a unidirectional arrow of time emerging from informational continuity. The theory reframes the “hard problem” of consciousness as a missing symmetry in fundamental physics—one connecting subjective experience, information, and spacetime structure. -/- . (shrink)

-/- Current physicalist models of consciousness, including Global Neuronal Workspace Theory and Integrated Information Theory, fail to resolve the unicity paradox inherent in perfect structural duplication. To resolve this limitation, I introduce a hybrid Quantum-Electrodynamic framework centered on a non-copyable Consciousness Identity Factor (CIF). I postulate that the CIF relies on localized Ultra-Quantum Genomic Particles that couple bidirectionally with the brain's macroscopic electromagnetic field topology. This paper formalizes the bidirectional resonance equations linking the quantum density matrix to Maxwellian field tensors. (...) Crucially, I present a falsifiable empirical parameter: a predicted 0.5 to 3.0 mV anomalous current injection that violates classical Hodgkin-Huxley electrodynamics during conscious states. I outline a rigorous experimental methodology utilizing dual somato-dendritic patch-clamp electrophysiology, high-density magnetoencephalography, and differential chemical ablation via Propofol and Xenon gas to isolate this quantum-biological interface. -/- . (shrink)

Social media applications such as Twitter, YouTube and Facebook have attained huge popularity, with more than three billion people and organizations predicted to have a social networking account by 2015. Social media offers a rapid avenue of communication with the public and has potential benefits for communicable disease control and surveillance. However, its application in everyday public health practice raises a number of important issues around confidentiality and autonomy. We report here a case from local level health protection where the (...) friend of an individual with meningococcal septicaemia used a social networking site to notify potential contacts. (shrink)

Current theories explain how neural activity relates to conscious experience but do not specify why one first-person perspective remains associated with one physical system rather than another when multiple systems satisfy the same functional or computational criteria. This article treats subjective continuity as a distinct scientific question. I develop a theoretical framework that proposes two hypothetical components with separate functions: X-UQUPC, which is proposed to preserve numerical conscious identity, and X-UQGPC, which is proposed to mediate bidirectional interactions between mental states (...) and neural activity. I examine whether this framework satisfies logical constraints arising from thought experiments involving brain reactivation, reconstruction, and replication, and I compare it with Global Neuronal Workspace Theory, Integrated Information Theory, Higher-Order Theory, predictive-processing accounts, functionalism, Orchestrated Objective Reduction, and Parfit's deflationary view of personal identity. I extend the analysis to non-human consciousness and gradual biological-to-synthetic neuronal replacement while treating both as open empirical questions rather than established conclusions. The framework generates explicit, falsifiable predictions and specifies conventional alternative explanations, experimental controls, and criteria for support and falsification. Several predictions are experimentally accessible with current or emerging neuroscience methods, whereas the central claim concerning numerical identity remains unobservable by construction. The value of the framework therefore depends not on the correctness of its assumptions but on whether its predictions withstand empirical testing. (shrink)

Subjective experience remains tied to the same individual despite continuous turnover of the brain’s physical components. Existing theories explain conscious content, neural mechanisms, and information processing, but none specifies the physical basis of numerical conscious identity or explains why one individual, rather than an identical duplicate, continues to experience consciousness. I propose the Ψ-I hypothesis: numerical conscious identity depends in part on a non-clonable quantum-information component that interacts weakly with neuroelectromagnetic dynamics without replacing established neurophysiology. The hypothesis yields five falsifiable (...) predictions in single-neuron electrophysiology, cortical traveling waves, magnetoencephalography, terahertz spectroscopy, and neural response thresholds. Each prediction defines a measurable residual relative to validated conventional models and states explicit falsification criteria. No direct evidence currently supports Ψ-I; its scientific value depends entirely on rigorous experimental testing and the outcome of those tests. (shrink)

The mechanisms underlying consciousness and its potential continuity beyond biological death remain pivotal challenges in neuroscience. This study integrates quantum biology, cognitive psychology, and thought experiments to propose a novel framework in which consciousness persists through hypothetical particles. Using three hypothetical scenarios—brain revival, molecular disassembly/reassembly, and synthetic brain reproduction—we explore whether consciousness arises solely from neural activities, from non-identified material components like certain microparticles, or from both. The results indicate that materialist models (e.g., the Orch-OR theory, Global Neuronal Workspace Theory (...) (GNWT), or Information Integration Theory (IIT)) fail to explain the uniqueness of self-awareness amidst the ever-changing quality and quantity of the brain. This failure necessitates the introduction of two hypothetical particles. These particles, posited to operate beyond classical physics, may mediate consciousness continuity by bonding with nascent nervous systems at infinite velocities. By bridging meditative insights with quantum biology, this study offers testable hypotheses for interdisciplinary research and emphasizes neuroplasticity and neurogenesis. However, brain function might impact quantum genome evolution as a one-way action via the magnetic field of neurons in the brain. Therefore: (1) there are limits in finding direct empirical facts of genomic particles; (2) nevertheless, we discuss several indirect evidence; and (3) the control experiments suggest no alternative other than a consciousness continuum after death. These findings suggest that optimizing mental practices (e.g., meditation) may: (a) enhance the evolution of intelligence, (b) scan the mind virus, (c) optimize decision-making and global well-being, (d) minimize personal and social issues, and (e) evolve the quantum genome for a better afterlife. (shrink)

Current theories of consciousness explain how physical activity gives rise to conscious experience. They do not explain why a particular first-person perspective remains attached to one physical system rather than another. Thought experiments involving brain reactivation, reconstruction, and replication expose this gap: physical and psychological duplication does not specify which resulting system, if any, carries forward the original subjective viewpoint. This article treats that gap as a distinct explanatory target and develops a candidate account, the two-particle model, built from two (...) functionally distinct hypothetical entities: X-UQUPC, proposed to confer identity persistence, and X-UQGPC, proposed to mediate bidirectional interaction between mental states and neural activity. I state the logical constraints the model must satisfy and give the strongest available alternative accounts a fair hearing, including deflationary, functionalist, and predictive-processing views. I then propose two experiments designed to discriminate the model from theories that treat consciousness as fully constituted by current computational or informational organization (Global Neuronal Workspace Theory, Integrated Information Theory, Higher-Order Theory, and predictive processing), and state plainly that no experiment can discriminate the model from Orchestrated Objective Reduction or test its core claim about which of several structurally identical systems, if any, continues a given perspective, since that claim is unobservable by construction rather than merely difficult to measure. For each remaining prediction I specify the expected observation, the leading conventional alternative explanation, the controls needed to distinguish them, and the criteria for support or falsification, without assigning numerical values the model cannot justify. The model’s value does not depend on it being correct; it depends on whether it can be tested and, if tested, shown to be wrong. (shrink)

Spinoza has been appropriated as a philosophical forefather of deep ecology. I identify what I take to be the relevant components of Spinoza’s metaphysics, which, at face value, appear to be harmonious with deep ecology’s commitments. However, there are central aspects of his moral philosophy which do not appear to be “environmentally friendly,” in particular the sentiments expressed in the Ethics IV35C1 and IV37S1. I describe environmental ethics’ treatment of these passages and then indicate what I take to be a (...) more satisfactory route toward “ecologizing Spinoza.”. (shrink)

Immortality and the Purpose of Life is an exhilarating voyage through the evolution of the universe which offers compelling answers to the fundamental questions of human existence. Dr. K.L. Reddy draws upon a deep and interdisciplinary investigation of geology, chemistry, biology, genetics, astronomy, philosophy, religion, and myth to distil the essence of the creative force, from non-life to life, from subatomic particle to the cosmic web to parallel universes. He deftly demonstrates how, through this alchemy of physical elements, material drives, (...) and human drama, one can achieve a most sublime spirituality and feel genuine hope for the future of humanity. (shrink)

Here, I discuss how natural biological evolution might have selected human origin and the psychology of the better mind-brain. However, all humans are closely related; why do we make crimes, war, hate, and jealousy their primary reasons and overcoming methodologies? How can they gain their best happiness? What kind of philosophy apply to annalize this big question and convince humankind to evolve their mind? How we could achieve our optimum potential happiness by developing hidden intelligence to make the world a (...) happier place to live in. (shrink)

This paper explores the classical Advaitic concept of Nididhyasana (deep contemplation), tracing its origins in the Brhadaranyaka Upanishad and examining its potential applications in contemporary philosophical counselling. Nididhyasana transcends mere meditation; it entails the profound assimilation of truth, following the stages of Sravana (hearing) and Manana (reflection). The Upanishadic dialogues, particularly those between Yajnavalkya and Maitreyi, serve as rich templates of experiential teaching that stand the test of time. This paper positions Nididhyasana as a potent tool for existential transformation, particularly (...) in contexts where philosophical clarity and ontological anchoring offer a viable path beyond modern psychological frameworks. Through a comparative and applicative approach, the paper advocates for Nididhyasana as an experiential modality, bridging the gap between metaphysical truth and practical life, and intriguingly shifting the focus from problem-solving to ontological grounding. (shrink)

L'auteur accepte la position d'auteurs comme Germain Grisez et John Finnis selon laquelle l'immoralité de l'homosexualité est connectée en quelque manière au dualisme esprit-corps de la recherche du plaisir. Il s'efforce pourtant, par une analyse de ce que Platon et Aristote disent au sujet du plaisir dans le Philebus et l'Ethique de Nichomaque, de décrire le genre - ou, plutôt, les genres - de dualisme dont il s'agit. Le résultat, pense-t-il, est une analyse qui évite la position insoutenable selon laquelle (...) le plaisir n'est en aucune manière à être poursuivi pour lui-même. Il est d'accord avec Aristote et Thomas d'Aquin que le plaisir est «une sorte de fin», qui reçoit son intelligibilité complète seulement lorsqu'elle accompagne des pratiques humaines pleinement intelligibles de façon isomorphique. (shrink)

In humanities departments across the country Allan Bloom is condemned and reviled—but for what misconduct? The present investigation into our distorted view of Bloom begins by reframing his transgressions. Bloom has offended eminent philosophy professors by boosting students' desire for a philosophic education. He has emboldened promising young people by teaching them to bear up under the deforming forces of convention and corruption and edge their way towards the question, ‘How should I live my life?’ A philosophic education as Bloom (...) sees it ‘means precisely helping students to pose this question to themselves, to become aware that the answer is neither obvious nor simply unavailable, and that there is no serious life in which this question is not a continuous concern’. The philosopher's interests are not shared by most people. Hostility to philosophy is the natural condition of man. This surprising fact, plainly stated, invites so much anger that Bloom—standing in for the philosopher—is forced to defend himself. The story of Bloom, like Socrates', gives an account of philosophy's emergence, distinctive features and always imaginable suppression. Plato's artful writing captured Socrates' way of life for posterity. This essay explores the nature and function of Bloom's bestselling book The Closing of the American Mind (1987), as well as the purpose of Saul Bellow's final novel, Ravelstein (2000), a fictive account of Bloom's life and death. Together these books amount to the true Apology of Allan Bloom. (shrink)

ABSTRACT Students’ positive perceptions of teachers’ caring behaviour have favourable outcomes, yet they have been little researched, especially in an Asian context. This study aims to establish a model explaining teachers’ caring behaviour (TCB) by testing multiple indicators. The survey instrument was administered to 296 students, whose responses were analysed using variance-based structural equation modelling (PLS-SEM). The results proved that modelling, teacher-student interactions (TSI), pedagogical caring (PC), and teachers’ dispositions (TD) were significantly associated with TCB. Findings suggest that TCB would (...) have a positive impact on the academic development and well-being of students. (shrink)

Philosophical Investigations, EarlyView.

Patrick Lee, professeur de philosophie à l'Université franciscaine de Steubenville, vient de publié un livre excellent sur la question de l'avortement : Abortion and Unborn Human Life . L'A. en présente le contenu et en commente l'actualité ainsi que la pertinence.

Faced with troubling professional decisions in his long and successful career as a psychiatrist, M. O'C. Drury turned for direction to the philosophical work of his teacher and friend, Ludwig Wittgenstein. Of particular concern to Drury were the situations in which psychiatrists were expected to differentiate between instances of madness that were religious in form and instances of genuine religious experience that, for their oddity, landed believers in psychiatric consulting rooms. In this essay we consider the special orientation Wittgenstein's philosophy (...) gave Drury, for example the way in which Drury came to understand how even his search for a principle of differentiation between madness and religion was misleading and contrary to his own practice—how it involved ‘sitting back in a cool hour and attempting to solve this problem as a pure piece of theory. To be the detached, wise, external critic’ and not see himself and his own manner of life ‘as intimately involved in the settlement of this question.’. (shrink)